Breeds

• The most common breed that is large, white and has blue eyes is the Siberian husky. Other possibilities are Great Danes, white German shepherd dogs, dalmatians and Samoyed.
  
  

Deafness

• According to VetInfo.com, deafness is most often found in breeds with white coats and blue eyes. The Dalmatian Club of America conducted hearing tests and concluded that breeding only bilaterally hearing, brown-eyed dalmatians is the best approach for reducing deafness. Dalmatians though, per breed standard, cannot be all white or have speckled noses.
  
  

Standards

• The white, blue-eyed, speckled-nose dog may not conform to breed standards as outlined by the American Kennel Club, Continental Kennel Club or other kennel and/or breed clubs. White German shepherd dogs and Samoyeds, for example, are disqualified for having blue eyes.